Welcome to The Heme Protein Database

The Heme Protein Database couples structural information on a non-redundant set of heme proteins with their associated electrochemical midpoint reduction potential values. The HPD incorporates the structural data on heme proteins in the RCSB Protein Data Bank (PDB) with the protein structure classifications in CATH 3.0.0 and electrochemical data from the primary literature. The data are presented along with MOLMOL images of the heme proteins and links to the Prosthetic Groups and Metal Ions in Protein Active Sites Database, PROMISE.

This heme protein structure-function database may be searched in one of the three ways presented at left. The Search by PDB ID feature allows the user to identify the properties of an individual heme protein. Data on sets of heme proteins can be retrieved using either the Detailed Search Function, which yields a list of all the individual members of the set, or the Global View function, which compiles the data on all the members of the set as a group.

Any Heme a Heme b Heme c Heme d Heme f Heme o P460 Siroheme Coproporphyrin

Any Four Five Six

Axial Ligands

Lig1 His Met Cys Tyr Lys Lig2 His Met Cys Tyr Lys Asn Nterm Water O2 N3 CN CO Acetate SO4 PO4

Em -600 -400 -200 0 +200 to Em +600 +400 +200 0 -200 -400

In citing the Heme Protein Database, please refer to:

Reedy, C.J.; Elvekrog, M.M.; Gibney, B.R. (2008) Development of a heme protein structure-electrochemical function database. Nucleic Acids Research, D307-D313.
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