Heme Protein Database

May 30, 2023

Welcome to The Heme Protein Database

The Heme Protein Database couples structural information on a non-redundant set of heme proteins with their associated electrochemical midpoint reduction potential values. The HPD incorporates the structural data on heme proteins in the RCSB Protein Data Bank (PDB) with the protein structure classifications in CATH 3.0.0 and electrochemical data from the primary literature. The data are presented along with MOLMOL images of the heme proteins and links to the Prosthetic Groups and Metal Ions in Protein Active Sites Database, PROMISE.

This heme protein structure-function database may be searched in one of the three ways presented at left. The Search by PDB ID feature allows the user to identify the properties of an individual heme protein. Data on sets of heme proteins can be retrieved using either the Detailed Search Function, which yields a list of all the individual members of the set, or the Global View function, which compiles the data on all the members of the set as a group.


Search by PDB ID  

Detailed Search

Global View

Secondary structure

Heme type
Coordination Number
Axial Ligands
Reduction Potential Range
Run Search

In citing the Heme Protein Database, please refer to:

Reedy, C.J.; Elvekrog, M.M.; Gibney, B.R. (2008) Development of a heme protein structure-electrochemical function database. Nucleic Acids Research, D307-D313.

The RCSB Protein Data Bank contains over 3000 hemes in 1400 heme protein entries. These 1400 entries were analyzed to provide a non-redundant set of 268 heme proteins, containing 738 hemes, for the Heme Protein Database. The HPD contains proteins with heme a, b (shown at left), c, d, f, and o cofactors along with those containing P460, siroheme and Fe(coproporphyrin). The CATH secondary structure classification for 241 of the 268 heme proteins is included in the HPD along with 157 heme reduction potential values ranging one volt, i.e. -550 mV to +450 mV vs. SHE.